Tartu scientists showed that people’s descent plays important role in genetic risk estimation
In a recently published article, Tartu scientists showed that unless an individual’s genetic descent is taken into account, his or her DNA-based estimation of disease risk may provide incorrect results.
In the case of many complex diseases, for example the coronary heart disease and the type 2 diabetes, the disease risk is not affected by one or two, but thousands or even tens of thousands of gene markers available in the human hereditary substance, DNA. Each one of them has a relatively small effect if taken separately but the aggregate impact is considerable.